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  Indian J Med Microbiol
 

Figure 3: Three proposed mechanisms of mannitol for lowering the intracranial pressure. First, it improves the cerebral perfusion pressure, as a result of the transient increase of the cardiac output. When cerebral autoregulation is preserved, this improvement causes reflex cerebral vasoconstriction, leading to an increase of the cerebrovascular resistance. Finally, the osmotic gradient generated diminishes the cerebral blood volume and improves the intracranial compliance. All these changes lead to a consistent improvement of the intracranial pressure

Figure 3: Three proposed mechanisms of mannitol for lowering the intracranial pressure. First, it improves the cerebral perfusion pressure, as a result of the transient increase of the cardiac output. When cerebral autoregulation is preserved, this improvement causes reflex cerebral vasoconstriction, leading to an increase of the cerebrovascular resistance. Finally, the osmotic gradient generated diminishes the cerebral blood volume and improves the intracranial compliance. All these changes lead to a consistent improvement of the intracranial pressure